Synthetic chemistry is scientific approach to new formation and preparation route for unknown compounds which have biologicals significance. In this book the evaluation of 1-3-(25-dimethoxy-4-methylphenyl)-5-substitutedphenyl-4 5-dihydro-1H-pyrazole Derivatives with its synthesis design spectroscopic evaluations through element analyses IR NMR MASS etc. and its efficacy toward some microbial evaluation.