5-Aryl 134 -Thiadiazole Derivatives As Potential Anticancer Agents

In search of new anticancer agents we have reported the synthesis of some 134-thiadiazoles. While designing target molecules we studied some reported HDAC (Histone deacetylases) inhibitor and from that we have used some fragments to design new target molecules. The reaction was monitored by TLC using suitable mobile phase and also determined the melting point of the Thiadiazole analogues. It is found that they were different from each other’s. Furthermore also characterized and confirmed by IR 1H-NMR and Mass spectral. For anticancer activity all the selected compounds were submitted to NCI (National Cancer Institute) for in vitro anticancer activity. Primary in vitro one dose anticancer assay was performed in full NCI 60 cell panel in accordance with the protocol of the NCI USA. The compound 5(a) and (6b) showed good activity against the all cancer cell lines at NCI USA