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???????? ???????????? ?????????? ? ?????????? ?????????? ????????? ???????????-?????????????? ??????????????? ??????? ???????? ???????? ?????????? ???????? ??????????? ? ????????? ???????????? ???????????? (HPMC) ? ??????????? (EC Eudragit RS 100) ?????????? ??????? ??????? ????? ? ???????????? ?? ??????????? ?????? ? ?????????????? 30% w/v ?????????????? ?? ????? ???????? ??????????? ? ???????? ?????????????? ? 20% w/v 30% w/v ?????????????????? (????? ????????) ? ???????? ????????? ????????????? ??? ???????????????? ????????????? ?????????. ????? ???? ??????????? ?????? ???????? ? ?????????????? ?????? ? ???? ?? ????????? ? ????????? ??????????? ?????????. ??? ??????????????? ???????? ???? ??????????? ??????-?????????? ??????: ??????? ????????? ???? % ?????????? ????? % ?????? ????? ????????? ??? ??????????? ????????????? ?????????? ????????? ? % ????????????? ?????????. . ???????????? ????????????? invitro ??????????? ? ??????? ???????????? ?????. ???????????? % ????????????? ????????? in-vitro ?????????? ? ??????? 48 ????? ? ?????????? F8 ?????????? HPMC: EC: Eudragit RS 100 ? ??????????? (5:0:1).
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