This Special Issue of the International Journal of Molecular Science comprises a comprehensive study on Metal Complex Interactions with Nucleic Acids and/or DNA. This Special Issue has been inspired by the important contribution of Prof. Nick Hadjiliadis to the field of palladium or/and platinum/nucleic acid interactions. It covers a selection of recent research and review articles in the field of metal complex interactions with nucleic acids and/or DNA. Moreover this Special Issue on Metal Comp