Origin of life on earth must be started from a story explaining how ribonucleic acids (RNAs) had been accumulated in azoic era. Since the world of nonazoic era could have been full of water a single molecule of RNA should have been in danger of hydrolysis rather than in a tendency of progressive synthesis. It necessarily requires coevolution of proteins that had been playing a role of protecting RNA from hydrolysis. The present book describes a possibility of a large-scale of confined organic phosphates and methane hydrates under high pressure and temperature deeply hidden into the mantle of the earth. In such conditions a polymeric form of D-ribose can be made as a left-handed helix connected by base pairs with neighboring strands. In the lattice of left-handed helices of RNA a lot of spaces or gaps allowed accumulation of various amino acids from the smallest one such as glycine to not very large as tryptophan. At the 3’ end of a polymeric RNA strand aminoacylation could also occur. The other essential substances to the origin of life such as adenine-triphosphates could have been accumulated together.
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