Since ancient times the utilization of traditional medicine was started and used all over the decades. Medicinal value of bitter melon has been attributed to its high antioxidant properties due in part to anthraquinones phenols isoflavones flavonoids terpenes and glucosinolates all of which confer a bitter taste. It contains biologically active chemicals that include glycosides saponins triterpenes alkaloids fixed oils steroids and proteins. Papaya is an important medicinal and economic plant with various pharmacological benefits and different nutritional benefits such as anti-inflammatory anti-cancer antidiarrheal antimicrobial larvicidal wound healing neuroprotective anxiolytic anti-diabetic hepatoprotective anti-obesity anti-hyperlipidemic anti-ulcerogenic anthelminthic and anti-thrombocytopenic activities. It also possesses high vitamin C and vitamin A values and various bioactive components with pharmacological activities.