<p>This Special Issue compiles a distinguished collection of peer-reviewed contributions advancing the field of prosthodontics with a particular focus on translational innovations in oral and maxillofacial rehabilitation. Encompassing original research clinical protocols and comprehensive reviews the articles investigate the mechanical biological and digital dimensions of modern prosthetic dentistry. Topics include finite element analyses novel biomaterials such as polyetheretherketone (PEEK) and titanium frameworks AI applications as well as digital workflows in implant and removable prosthodontics. The assembled works offer a rigorous examination of both in vitro performance and clinical implementation providing a forward-looking perspective on minimally invasive functional and esthetic rehabilitation. This reprint serves as a reference point for clinicians researchers and policymakers dedicated to elevating the standards of prosthetic care through scientific excellence and interdisciplinary collaboration.</p>
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