<p><span style=color: rgba(23 43 77 1)>Psychosocial care is critical to supporting the adjustment coping and quality of life of children and families from the time of diagnosis throughout treatment and into survivorship or through end-of-life care and bereavement. Now a standard of care in pediatric oncology psychosocial support is considered essential for all children and families. Interprofessional team members collaborate on assessment intervention education and research to advance the science and practice of pediatric psycho-oncology.</span></p><p><span style=color: rgba(23 43 77 1)>This Special Issue in&nbsp;</span><em style=color: rgba(23 43 77 1)>Cancers</em><span style=color: rgba(23 43 77 1)>&nbsp;highlights Advances in Pediatric and Adolescent Psycho-Oncology including but not limited to studies focusing on social emotional and behavioral outcomes of childhood cancer; quality of life during active treatment transition off treatment or during survivorship; palliative care end-of-life care and bereavement; and psychosocial interventions for patients and families (e.g. caregivers siblings).&nbsp;This Special Issue includes manuscripts that elevate patient and family voices and provide new insights in the field of pediatric and adolescent psycho-oncology.</span></p>