Algorithms for Sample Preparation with Microfluidic Lab-on-Chip

Recent microfluidic technologies have brought a complete paradigm shift in automating biochemical processing on a tiny lab-on-chip (a.k.a. biochip) that replaces expensive and bulky instruments traditionally used in implementing bench-top laboratory protocols. Biochips have already made a profound impact on various application domains such as clinical diagnostics DNA analysis genetic engineering and drug discovery among others. They are capable of precisely manipulating micro-/pico-liter quantities of fluids and provide integrated support for mixing storage transportation and sensing on-chip. In almost all bioprotocols sample preparation plays an important role which includes dilution and mixing of several fluids satisfying certain volumetric ratios. However designing algorithms that minimize reactant-cost and sample-preparation time suited for microfluidic chips poses a great challenge from the perspective of protocol mapping scheduling and physical design. Algorithms for Sample Preparation with Microfluidic Lab-on-Chip attempts to bridge the widening gap between biologists and engineers by introducing from the fundamentals several state-of-the-art computer-aided-design (CAD) algorithms for sample preparation with digital and flow-based microfluidic biochips. Technical topics discussed in the book include: Basics of digital and flow-based microfluidic lab-on-chipComprehensive review of state-of-the-art sample preparation algorithmsSample-preparation algorithms for digital microfluidic lab-on-chipSample-preparation algorithms for flow-based microfluidic lab-on-chip