In this book we reported that amphiphilic dendrimer is stabilizing agent for the formation of trimetallic nanoparticles viz. Ag/Pd/AuNPs and Fe/Pt/RuNPs. The catalytic potential of these catalysts were examined by conducting the reduction of p-nitrotoluene & malachite green reactions and oxidation of 3 3'' 5 5'' - tetramethyl benzidine & Ascorbic acid. From the observed results it reveals that the newly developed amphiphilic dendrimer stabilized/encapsulated homogeneous trimetallic nanoparticles can be an efficient catalyst to reduce the environmentally important organic pollutants. Further one of the trimetallic nanoparticle catalyst containing Fe/Pt/RuNPs shows excellent peroxidase/oxidase-like activity for TMB and AA substrates