This book is useful for pharmacy post graduate students and research scholars who wish to pursue their research in the field of pharmaceutical analysis. In this book Chapter 1 deals with the aim objective and general introduction regarding analytical method development optimization and validation. Chapter 2 deals with the literature survey of the selected drugs namely Cefpirome Sulphate Aceclofenac and Diacerin. Chapter 3 deals with the HPLC methods developed for Cefpirome Sulphate Aceclofenac and Diacerin. Chapter 4 deals with UV methods developed for these drugs. Chapter 5 deals with the summery and conclusion. References are included at the end.