Anti-cancer effects of ��-mangostin on human breast cancer cell lines

In this book α-mangostin (AM) a xanthone compound was investigated for its apoptosis mechanism on MCF-7 and MDA-MB-231 cell lines. The treatment of the cells with AM prompted apoptosis with cell death-transducing signals. This type of apoptosis was suggested to occur through the both extrinsic and intrinsic pathways and prevention of translocation of NF-κB from the cytoplasm to the nucleus. Our results revealed AM prompt apoptosis of the both cells through NF-κB Bax/Bcl-2 and HSP70 protein modulation with the contribution of caspases. Therefore AM is deemed to have considerable potential in the control of breast cancer.