<p><span style=color: rgba(23 43 77 1)>This reprint highlights recent developments in computational biology deep learning algorithms and cancer biology that enable the decoding of the cancer genome and tumor microenvironment ecosystem. One of its major focuses is on the integration of multi-omics data such as WGS WES scRNAseq spatial transcriptomics and proteomics along with radiomics and digital pathology to better understand cancer initiation evolution drug-tolerant persister cancer states and full therapy resistance. Unbiased systematic analyses using artificial intelligence machine learning and deep learning approaches could advance our knowledge and improve cancer treatment. In this reprint leading experts in the field share their insights research findings and visions for the future of cancer informatics. Cutting-edge computational approaches and bioinformatics algorithms provide powerful toolkits to systematically identify clinically relevant biomarkers for early cancer diagnosis prognosis and precision cancer therapy stratification.</span></p><p><br></p><p><br></p><p><br></p>
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