Aim to design and synthesis of artificial calixarene and fullerene based therapeutic applicable molecules. This book emphasis on functionalization of calix[4]arene and fullerene based heterocyclic scaffolds and its applications in various areas such as antimicrobial activity anti-oxidant activity anti-tubercular activity anti-cancer activity anti-HIV activity anti-malarial activity DNA cleavage studies and inclusion complexation. This studies also supported by Insilico based computational investigation.