Arginase Enzyme in Iraqi Acromegaly Patients

L-arginase (EC 3.5.3.1) the final enzyme in the urea cycle is a binuclear Mn2+ metalloenzyme. The enzyme catalyzes a reaction involving the hydrolysis of L-arginine to L-ornithine and urea. Acromegaly (ACRO) is a rare and complex hormonal syndrome classified as a chronic disorder characterized by elevated growth hormone (GH) and consequently insulin-like growth factor-1 (IGF-1). This is commonly caused by a GH-secreting pituitary adenoma leading to multisystem impacts. These impacts affect the osteoarticular system muscles brain heart and blood vessels respiratory and hematopoietic system kidneys liver and pancreas thyroid adipose tissue and metabolic system. The objective of this study is to evaluate the levels of arginase activity GH IGF-1 glucose lipid profile and serum urea in ACRO patients with and without diabetes. Additionally the study aims to explore the correlation between Arginase and GH glucose and lipid profile.