Assessment of the Effect of Copper Complex on Autophagy in TNBC cells

Autophagy is a well-maintained process by which cells recycle intracellular materials to keep up homeostasis in various cellular settings. However autophagy is a defensive mechanism that maintains cell survival under antagonistic conditions the induction of autophagic process may substantially lead to cell death. The conflicting role of autophagy including allowing cell survival or promoting cell death could have troublesome impact on the efficiency of chemotherapeutic agents . The current interest in copper complexes e.g. copper (I)- originated from their expanded spectrum of activity as antimicrobial antiviral anti-inflammatory antitumor agents. Copper complexes frequently targeted apoptosis as a mechanism of cell death. However the clarification of other mechanisms involved in the anti-proliferative activity of copper (I)-complexes (autophagy) may facilitate the generation of new era of copper drug