ATORVASTATIN SELF-EMULSIFIED TABLETS FORMULATION AND EVALUATION

Due to poor drug solubility and absorption many drug candidates fall short of expectations. Self-emulsifying drug delivery methods increase the solubility and bioavailability of poorly soluble medications. When SEDDS are added to an aqueous phase and gently mixed fine oil-in-water emulsions form. SEDDS come in soft or hard gelatin capsules for oral administration and form fine stable oil-in-water emulsions. SEDDS are primarily manufactured as liquid formulations which have poor stability and mobility low drug loading a limited number of dosage form options irreversible drug/excipient precipitation and a high proportion (30–60%) of surfactants that might irritate the gastrointestinal system. Solid-SEDDS has been studied to avoid the problems of liquid SEDDS. The adsorption of liquid self-micro-emulsified formulations on solid carriers is one of the best ways to create free-flowing powders for compression into tablet dosage form (SMET).