In this book we try to link between amazing phenomenon (Autophagy) and Fasting. Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome. Despite its simplicity recent progress has demonstrated that autophagy plays a wide variety of physiological and pathophysiological roles which are sometimes complex. Autophagy consists of several sequential steps—sequestration transport to lysosomes degradation and utilization of degradation products—and each step may exert different function.