This book contains an update on b-cell non hodgkin lymphoma treatment. it also clarifies the state of the art in the treatment of the four basic subtypes of b-cell diffuse large b-cell marginal zone mantle zone and follicular lymphoma. This work shed the light on the new treatment options including type I and II anti CD 20. since biology is the corner stone on which all treatment options are designed we tried to make the link between the basic and clinical application so the former idea is clear in all chapters of the book.