B cell specificity and pattern in primary Sj��gren's syndrome

Sjögren’s syndrome (SS) is a chronic autoimmune disease characterised by focal inflammation of the salivary and lacrimal glands resulting in the common symptoms of dry eyes and dry mouth. Here mononuclear cells including B cells infiltrate the glands leading to their dysfunction and later destruction. Another distinctive feature is the systemic production of autoantibodies that results from the activation of B cells into antibody secreting plasma cells. Hence although the etiology of SS remains unclear B cells do play an important part in the pathogenesis of this disease. In this doctoral work we explore the immunological process while addressing the concept of B cell specificity and pattern in primary SS (pSS). We consider both the general and the autoantigen-specific B cell pattern in the peripheral blood and the salivary glands of patients with pSS and also account for the expression pattern of the Ro52 autoantigen. Furthermore we explore a congenic NOD mouse strain namely NOD.B10.H2b in order to characterise the plasma cell compartment in the parotid and submandibular salivary glands and in the bone marrow.