Basics of Drug Discovery and Development : DHFR as a theraputic target

This book indicates the importance of QSAR to optimize the discovery of drugs at a low cost and on occasions to change their pharmacokinetic and pharmacodyanamic properties. The section on QSAR highlights the role of physicochemical parameters in predicting the future course of drug discovery with rational drug design. Pharmacophore based drug design has been now considered as a powerful approach and has found wide applications in drug design because of the pressing need to reduce the time & cost of candidate drug molecule in discovery phase where the current emphasis is on more rational approaches than trial and error to identify new chemical entities (NCE). In view of this and the urgency to identify new dihyrofolate reductase (DHFR) inhibitors.