<p>Dear Colleagues</p><p>The importance of bioactive natural compounds in pharmacology and other biotechnological fields has stimulated the scientific community to explore new environmental contexts and their associated microbial diversity. As the largest frontier in biological discovery the sea represents a significant source of organisms producing novel secondary metabolites with interesting bioactivities. Of the available biological material fungi have received increasing consideration both due to their pervasive occurrence in varying habitats as well as their aptitude to develop symbiotic associations with higher organisms in numerous contexts. In many cases fungal strains have been reported as the real producers of drugs originally extracted from marine plants and animals. Due to the constantly increasing number of marine-derived fungi yielding valuable bioactive products it is now appropriate to present these findings to a recipient audience in a more organized form.</p><p>This Special Issue of Marine Drugs entitled &ldquo;Bioactive Compounds from Marine-Derived Aspergillus Penicillium Talaromyces and Trichoderma Species&rdquo; is specifically focused on a few genera of ascomycetous fungi which are widespread regarding marine contexts and are particularly inclined to establishing symbiotic relationships. For this project we welcome submissions of full research papers short notes and review articles reporting the discovery and characterization of products showing antibiotic antitumor antiviral insecticidal antimalarial antifouling antioxidant plant growth-promoting and/or resistance-inducing as well as other less-exploited activities.</p><p>Dr. Rosario Nicoletti<br />Dr. Francesco Vinale<br />Guest Editors</p>