<p><span style=color: rgba(23 43 77 1)>Bioactive natural products can be found among animals terrestrial or marine microorganisms herbs and plants. This Special Issue consists of two reviews and ten research articles; the reviews explored current knowledge on the antimicrobial activity of Latin American plants and the constituents of different&nbsp;</span><em style=color: rgba(23 43 77 1)>Solanum</em><span style=color: rgba(23 43 77 1)>&nbsp;members and their pharmacological properties with some emphasis on their mechanism of action. On the other hand the research articles consisted of documenting the phytochemistry and the biological activities of plant species such as&nbsp;</span><em style=color: rgba(23 43 77 1)>Laelia furfuracea</em><span style=color: rgba(23 43 77 1)>&nbsp;</span><em style=color: rgba(23 43 77 1)>Melaleuca quinquenervia</em><span style=color: rgba(23 43 77 1)>&nbsp;</span><em style=color: rgba(23 43 77 1)>Puya chilensis</em><span style=color: rgba(23 43 77 1)>&nbsp;</span><em style=color: rgba(23 43 77 1)>Fluorensia retinophylla</em><span style=color: rgba(23 43 77 1)>&nbsp;</span><em style=color: rgba(23 43 77 1)>Tigridia vanhouttei</em><span style=color: rgba(23 43 77 1)>&nbsp;</span><em style=color: rgba(23 43 77 1)>Kalanchoe fedtschenkoi</em><span style=color: rgba(23 43 77 1)> and a new garden rose genotype. Also an article explores the structure</span><strong style=color: rgba(23 43 77 1)>-</strong><span style=color: rgba(23 43 77 1)>activity relationship of natural and synthetic derivatives of chalcones and dihydrochalcones against&nbsp;</span><em style=color: rgba(23 43 77 1)>Saprolegnia</em><span style=color: rgba(23 43 77 1)>. Other works report the potential of&nbsp;</span><em style=color: rgba(23 43 77 1)>Lafoensia replicata</em><span style=color: rgba(23 43 77 1)>&nbsp;as a potential cosmetic preservative and the chemical variation of leaves and pseudobulbs of the Mexican endemic orchid&nbsp;</span><em style=color: rgba(23 43 77 1)>Prosthechea karwinski</em><span style=color: rgba(23 43 77 1)>. Due to all the above the&nbsp;</span><em style=color: rgba(23 43 77 1)>Bioactivities of Natural Products</em><span style=color: rgba(23 43 77 1)>&nbsp;Special Issue is a fascinating book that updates or reports knowledge on plants' chemistry and biological activities for the first time.</span></p>