Biocatalysis in the Pharmaceutical and Biotechnology Industries

<p>Because enzyme-catalyzed reactions exhibit higher enantioselectivity regioselectivity substrate specificity and stability they require mild conditions to react while prompting higher reaction efficiency and product yields. <b>Biocatalysis in the Pharmaceutical and Biotechnology Industries</b> examines the use of catalysts to produce fine chemicals and chiral intermediates in a variety of pharmaceutical agrochemical and other biotechnological applications.</p><p>Written by internationally recognized scientists in biocatalysis the authors analyze the synthesis of chiral intermediates for over 60 brand-name pharmaceuticals for a wide range of drug therapies and treatments. From starting material to product the chapters offer detailed mechanisms that show chiral intermediates and other by-products for each reaction—including hydrolytic acylation halogenation esterification dehalogenation oxidation-reduction oxygenation hydroxylation deamination transamination and C–C C–N C–O bonds formation. Cutting-edge topics include advanced methodologies for gene shuffling and directed evolution of biocatalysts; the custom engineering of enzymes; the use of microbial cells and isolated biocatalysts; the use of renewable starting materials; and generating novel molecules by combinatorial biocatalysis and high-throughput screening. </p><p>Focusing on industrial applications the book also considers factors such as bulk processes instrumentation solvent selection and techniques for catalyst immobilization reusability and yield optimization throughout. <b>Biocatalysis in the Pharmaceutical and Biotechnology Industries</b> showcases the practical advantages and methodologies for using biocatalysts to develop and produce chiral pharmaceuticals and fine chemicals.</p>