A detailed work made to find out the impact of sodium arsenate in the mammalian model albino mice. Hematological parameters like Red blood corpuscles (RBC) Hemoglobin (HB) Packed cell volume (PCV) count decreased and White blood corpuscles (WBC) increased. carbohydrate count reduced in experimental animals. SDH levels were decreased histological studies proved that there is a architectural alterations in tissue of Liver Kidney and muscle.