BLAME! 1

In a future version of Earth there is a city grown so chaotically massive that its inhabitants no longer recall what land is. Within this megastructure the silent stoic Kyrii is on a mission to find the Net Terminal Gene—a genetic mutation that once allowed humans to access the cybernetic NetSphere. Armed with a powerful Graviton Beam Emitter Kyrii fends off waves of attacks from fellow humans cyborgs and silicon-based lifeforms. Along the way he encounters a highly-skilled scientist whose body has deteriorated from a lengthy imprisonment who promises to help Kyrii find the Net Terminal Gene once she settles a score for herself...