<p>With the advancements in the medical and scientific fields the global community has acquired a comprehensive understanding about brain insults and pathologies. In addition new findings and discoveries are being made globally every day which keep our curiosity high and drive a knowledge gain. Any brain insult or pathology is multifactorial including a cascade of inflammation necrotic and apoptotic pathways; can be influenced by genetic or environmental factors; and may lead to chronic neurodegeneration or disabilities.&nbsp;This Special Issue entitled Brain Injury and Neurodegeneration: Molecular Functional and Translational Approach has addressed various important aspects of brain injury and neurodegeneration such as TBI cerebral hypoxia epilepsy AD and SARS-CoV-2-mediated brain damage. It received appreciable global response and published 18 peer-reviewed articles including 10 research articles and 8 reviews. Briefly it explores the recent coronavirus infection-mediated cerebral damage; discusses the mechanism of TBI ischemia hypoxia and epilepsy; talks about neurodegenerative diseases such as Alzheimer's disease Parkinson's disease and CONDCA; and finally reviews the translational values of phytochemicals in brain pathologies. In conclusion this Special Issue provides a unique review on brain injury and neurodegeneration and will be a good tool in enhancing knowledge in terms of brain disease-related pathology mechanisms and translational approach.</p>
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