Alzheimer's disease (AD) is the most well-known neurodegenerative disorder causing dementia. In recent decades several studies have reported calcium dysregulation in AD occurring through the intervention of several calcium receptors and channels and affecting different cellular compartments such as mitochondria the endoplasmic reticulum lysosomes and microdomains within the plasma membrane. Calcium signalling dysregulation is now considered a common proximal cause of dysfunctional neurons and gl