Cardio-renal syndrome

Kidney failure is detected in over a third of heart failure patients. The association of these two pathologies has a poor prognosis as it often alters the therapeutic strategy recommended for heart failure patients and increases the progressive damage to both organs. The kidney plays an important role in the pathophysiology of heart failure and suffers the progressive consequences of the most common causes of heart failure: ventricular dysfunction atherosclerosis hypertension and diabetes. Because these patients with renal failure and heart failure are often excluded from controlled trials little is known about their optimal treatment and recommended medications. The cardio-renal syndrome is a hot topic with various studies highlighting its increasing frequency and therapeutic implications. It can have detrimental consequences as it exacerbates the effects of neurohormonal stimulation inflammation oxidative stress and endothelial dysfunction on the structure of the myocardium vessels and kidneys.