Cardioprotective Activity of Agaricus bisporus

The present research was designed to appraise the cardioprotective activity of a hydroalcoholic extract of Agaricus bisporus (EEAB) on Isoproterenol (ISO) induced myocardial infarction (MI) in Albino Wistar rat. Traditionally Agaricus bisporus is reported in the treatment of heart diseases cancer cerebral stroke and anti-ageing property.Wistar rats of different sex were randomly split into five groups namely positive control negative control standard test-1 and test-2 and received distilled water ISO (85 mg/kg) Simvastatin (10 mg/kg/day oral) and EEAB (200 and 400 mg/kg/day p.o.) for 30 days respectively. MI was induced in rats by ISO at an interval of 24 hrs on 31 and 32 day and on the next day blood was amassed through retro-orbital plexus for the assessment of biochemical markers (cholesterol lowdensity lipoprotein high-density lipoprotein very low-density lipoprotein triglycerides alanine aminotransferase and total protein) and finally the rats were immolated by cervical dislocation. It can be an outcome that EEAB possessed cardioprotective activity against experimental and clinical studies of ISO-induced myocardial infarction in rats.