CCNB1 CCNB2 CCNA1 CCNA2 SYT1 SYT2 CKS2 CKS1B CCNB3 SKP1 CDK1 RPS23 RPS27A ZFAND4 RPS27 RPS27l BUB1 BUB1B could play significant roles in the aetiology of schizophrenia by acting as points of contact between ALDH18A1 and SEC23IP (COP2).

Fourteen genes and their paralogues (CCNB1 CCNB2 CCNA1 CCNA2 SYT1 SYT2 CKS2 CKS1b CCNB3 RPS23 RPS27A ZFAND4 RPS27 RPS27l BUB1 BUB1B SKP1 CDK1) which putatively act as points of contact between ALDH18A1 and COP2 associated genes particularly SEC23IP and CSNK1D are identified which could play significant roles in the aetiology of schizophrenia. Many of these genes are found at the same genetic locations as deletion/duplication disorders and/or CNVs that have been reported on as being associated with schizophrenia. A partial failure of SEC23IP binding is identified as a possible cause of symptoms of 22q Parkinson's disease. Proline residues are identified as possible treatment targets in 22q Parkinson's disease.