Chemotherapy Analysis in Massive Transfusion Syndrome

Massive transfusion is defined as blood transfusion in quantities equal to or greater than the estimated patients’ blood volume over a relatively short period of time (3-4 hours). The study was aimed at analyzing the application of chemotherapy in treatment of patients with acute massive bleeding and evaluating the results of hemostasis and platelet counts screening tests in the patients receiving massive transfusions. In our study we have confirmed the pathophysiological mechanism shown in the available medical literature that after transfusion of a large red blood cell concentrate volume dilutional coagulopathy develops caused by a sharp drop in platelet count and the significantly reduced activity of unstable coagulation factors in the patient''s circulation.