Chromosome Segregation and Aneuploidy

Aneuploidy - the greatest genetic affliction of man - has its origin in manycellular processes. Its forerunner chromosome non-disjunction can result from malfunction of one of many processes involved in faithful segregation of chromosomes during mitosis or meiosis. Experts on chromosome biology centromere kinetochore microtubules spindle apparatus biochemistry of mitosis and meiosis developmental biology and environmental mutagenesis discuss basic and applied aspects of how chromosomes malsegregate and how aneuplody originates. The most recent techniques employed to study chromosome segregation and also methods to determine aneugenic chemicals are described.