Cilia and Mucus

<p>This book details advances in research regarding cilia, mucus, and mucociliary clearance, examining changes in mucus expression and goblet cell metaplasia, and assessing the ability of the mucociliary system to respond to abnormalities. <br>Recognizes that cilia and dynein arms play pivotal roles in developing mammalian embryos!<br>Examines the role of genetics in normal and abnormal ciliary function!<br>Discussing scientific fundamentals, current diagnostic techniques, and clinically tested treatments, Cilia and Mucus </p><li> analyzes the regulation of ciliary waves at the cellular level <br> </li><li> considers irregularities of upper and lower airways and cilia in systems of the body <br> </li><li> explores potential modulators of airway mucin secretion <br> </li><li> proposes a novel therapy for airway hypersecretion due to the epidermal growth factor cascade <br> </li><li> clarifies gamma camera imaging to measure mucociliary clearance <br> </li><li> describes the effect of purinergic receptors and dry powder mannitol on airway passages <br> </li><li> and more! <br>With contributions from over 100 international researchers and clinicians, and containing over 1300 references, drawings, photographs, tables, and equations, Cilia and Mucus is a unique single-source reference for pulmonologists, physiologists, immunologists, allergists, otolaryngologists, pediatricians, microbiologists, basic scientists, and graduate and medical school students in these disciplines.</li> <p>CILIA<br><br>Cytoplasmic Dynein-2 and Ciliogenesis<br>David J. Asai<br>Dynein Motor Activity During Ciliary Beating<br>Michael E. J. Holwill<br>Ciliary Growth by Intraciliary Trafficking<br>Dawn Signor, Karen P. Wedaman, Jose T. Orozco, Lesilee S. Rose, and Jonathan M. Scholey<br>The Regulation of Airway Ciliary Beat Frequency by Intracellular Calcium<br>Michael J. Sanderson, Alison B. Lansley, and John H. Evans<br>Modeling the Response of Mammalian Ciliary Beating to Changes in Cytoplasmic Calcium<br>Matthias Salathe and Richard J. Bookman<br>Enhancement of CBF Is Dominantly Controlled by PKG and/or PKA<br>Alex Braiman, Natalya Uzlaner, and Zvi Priel<br>Modulation of Ciliary Motility by Na+<br>Shai D. Silberberg, Alon Korngreen, Weiyuan Ma, Natalya Uzlaner, and Zvi Priel<br>Presentation of Ciliary Beat Frequency Results to Our Peers<br>X. Mwimbi, R. Muimo, and Anil Mehta <br>Identifying the Genes for Primary Ciliary Dyskinesia and Kartagener Syndrome<br>Michal Witt, Ewa Rutkiewicz, Yue-Fen Wang, Cui-e Sun, Diego F. Wyszynski, Scott R. Diehl, Jacek Pawlik, and Jerzy Zebrak<br>Homozygosity Mapping as an Approach for Identifying Genes Involved in Primary <br>Ciliary Dyskinesia S. L. Spiden and H. M. Mitchison<br>Mutations in the Novel Mammalian Gene DNAI1 Result in Primary Ciliary Dyskinesia<br>Gaëlle Pennarun, Catherine Chapelin, Anne-Marie Bridoux, Valère Cacheux, Michel Goossens, Serge Amselem, Bénédicte Duriez, Estelle Escudier, Gilles Roger, and Annick Clément<br>Molecular Strategies for the Study of Human Cilia <br>Lawrence E. Ostrowski<br>Ciliated Ependymal Cells: The Effect of Streptococcus pneumoniae on the Beat Frequency Response <br>Robert A. Hirst, T. J. Mitchell, P. W. Andrew, and C. O'Callaghan<br>The Cytoprotective Effects of Macrolides, Azalides, and Ketolides on Human Ciliated Epithelium In Vitro <br>Charles Feldman, Ronald Anderson, Annette J. Theron, Peter Cole,and Robert Wilson<br>Examining Mucociliary Differentiation of Human Nasal Epithelial Cells In Vitro<br>J. Laoukili, K. Million, O. Houcine, F. Marano, Frédéric Tournier, E. Perret, and D. Caput<br><br>MUCUS<br><br>Respiratory Tract Mucins <br>Julia R. Davies and Ingemar Carlstedt<br>MARCKS Protein: A Potential Modulator of Airway Mucin Secretion<br>Yuehua Li, Linda D. Martin, and Kenneth B. Adler<br>Airway Goblet and Mucous Cells: Identical, Similar, or Different?<br>C. William Davis and Scott H. Randell <br>Regulation of Respiratory Mucin Gene Expression by Neutrophil Elastase<br>Judith A. Voynow and Bernard M. Fischer<br>Pseudomonas Adhesion to MUC1 Mucins: A Potential Role of MUC1 Mucins in Clearance of Inhaled Bacteria <br>Kwang Chul Kim, Sang Won Hyun, Beom Tae Kim, Daoud Meerzaman, Min Ki Lee, and ErikLillehoj<br>High-Density DNA Microarray Membranes to Study Gene Expression Patterns Associated with Human Airway Epithelial Cell Differentiation in Culture<br>Mary M. J. Chang, Yin Chen, Yu Hua Zhao, Reen Wu, Ching Li, and Konan Peck<br>In Vivo Models of Airway Goblet Cell Hyperplasia and Mucin Gene Expression<br>Alinka K. Smith and Duncan F. Rogers<br>Interleukin-13-Induced Mucous Cell Hyperplasia in Airway Epithelium <br>Linda D. Martin, Brian W. Booth, Nancy J. Akley, Kenneth B. Adler, Mariangela Macchione, and James C. Bonner<br>Airway Mucins and Lung Cancer <br>Chong-Jen Yu and Pan-Chyr Yang<br>Charged Oligosaccharides as Novel Mucolytic Therapies <br>Malcolm King, Eiichi Sudo, and Martin M. Lee<br><br>MUCOCILIARY INTERACTIONS<br><br>Modeling Aspects of Tracer Transport in Mucociliary Flows<br>J. R. Blake and E. A. Gaffney<br>P2Y2 Receptors and Ca2+-Dependent Cl- Secretion in Normal and Cystic Fibrosis Human Airway Epithelia <br>Carla M. Pedrosa Ribeiro, Anthony M. Paradiso, Eduardo Lazarowski, and Richard C. Boucher <br>Role of Epidermal Growth Factor Receptor Cascade in Airway Hypersecretion and Proposal for Novel Therapy <br>Jay A. Nadel <br>In Vivo Measurement of Mucociliary Clearance: The Use of Gamma Camera Imaging<br>Joy Conway<br>Regulation of Mucociliary Clearance by Purinergic Receptors<br>William D. Bennett, Peadar G. Noone, Michael Knowles, and Richard C. Boucher<br>The Effect of Dry Powder Mannitol on the Clearance of Mucus<br>Evangelia Daviskas, Michael Robinson, Sandra D. Anderson, and Peter T. P. Bye<br>Neutrophil Elastase and Antigen-Induced Mucociliary Dysfunction<br>Thomas O'Riordan and William M. Abraham<br>Mechanisms of Clearance of Soluble Substances from the Intrathoracic Airways<br>W. Michael Foster and Elizabeth M. Wagner<br>The Role of Cough in Lung Mucus Clearance <br>Amir Hasani and John E. Agnew<br>Cough Clearance of Mucus Simulants in Endotracheal Tubes: Patterns of Catastrophic Separation at Controlled Linear Velocities <br>Peter Krumpe, Bruce Denney, Amgad Hassan,Ross Albright, and Cahit Evrensel</p>