Clear Cell Lesions of Head & Neck

In head and neck region clear cell can originate from various sources and are more commonly seen in odontogenic tumors salivary gland tumors metastatic carcinomas. Clear cell tumors are tumor cells that have vacuolated or clear cytoplasm in routine hematoxylin and eosin stain. In Maxillo facial areas clear cell are found in many benign and malignant tumors arising from epithlial mesenchymalmelanocytic and hematopoietic derivation cell lines. Tumor with clear cells can impose a diagnostic dilemma for the surgical pathologist with respect to differential diagnosis which extends as a therapeutic dilemma for the managing surgeons.