Periodontal regeneration is the restoration of lost or diminished periodontal tissues including cementum periodontal ligament and alveolar bone. Guided tissue regeneration is a surgical procedure with the goal of achieving new bone cementum and PDL attachment to a periodontally diseased tooth using barrier devices or membranes to provide space maintenance epithelial exclusion and wound stabilization.4 Periodontal regeneration is a multi factorial process and requires an orchestrated sequence of biological events including cell adhesion migration multiplication and differentiation. Periodontal regeneration aims at an increase in the periodontal attachment of a severely compromised tooth a decrease in pocket depth and no or minimal gingival recession.