Colon Specific Diloxanide Furoate Delivery using Microspheres

The colon is attracting interest as a site where poorly absorbed drug molecule may have an improved bioavailability. This region of the colon is recognized as having a somewhat less hostile environment with less diversity and intensity of activity than the stomach and small intestine. Additionally the colon has a longer retention time and appears highly responsive to agents that enhance the absorption of poorly absorbed drugs. Apart from retarding or targeting dosage forms a reliable colonic drug delivery could also be an important starting position for the colonic absorption of per orally applied undigested unchanged and fully active peptide drugs.