Comparing Clustering Algorithms for Use With Genomic and Proteomic Data

<p>The Human Genome Project and related projects have resulted in the development of a number of new experimental and analytic tools for use in genomic and proteomic research. In the area of toxicogenomics researchers are concerned with how genes react to exposure to certain chemicals. The United States Air Force is interested in the effect of exposure to mission-essential chemicals. Although military personnel may come into contact with chemicals such as hydrazine risk assessment is usually very limited. On the genomic level risk assessment is a multi-step and multi-disciplinary process. The process begins with an experiment that exposes cells to the chemical. Data from the experiment are obtained using gene chips. The data can then be analyzed. This research explores the methods of pre-processing and analyzing data. Several different data sets are used to compare the effectiveness of various clustering algorithms and their implementations. Genomic and proteomic data obtained from a hydrazine exposure experiment are then analyzed. A relationship is established between the genomic and proteomic data sets and is used in further analyses.</p><p>This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact and remains as true to the original work as possible. Therefore you will see the original copyright references library stamps (as most of these works have been housed in our most important libraries around the world) and other notations in the work.</p><p>This work is in the public domain in the United States of America and possibly other nations. Within the United States you may freely copy and distribute this work as no entity (individual or corporate) has a copyright on the body of the work.</p><p>As a reproduction of a historical artifact this work may contain missing or blurred pages poor pictures errant marks etc. Scholars believe and we concur that this work is important enough to be preserved reproduced and made generally available to the public. We appreciate your support of the preservation process and thank you for being an important part of keeping this knowledge alive and relevant.</p>