<p class=ql-align-justify>This reprint immerses readers in the latest advancements in the computational and mathematical modeling of neural systems with a focus on brain functionality. It explores foundational principles established models and emerging technologies that are shaping the future of computational neuroscience. By integrating theoretical foundations with empirical data the approaches presented not only enhance our understanding of neural dynamics but also pave the way for transformative applications in clinical practice and therapeutic innovation. This special issue underscores the pivotal role of computational methodologies-including machine learning network analysis brain-computer interfaces and predictive modeling-in unraveling the complexities of brain function cognition and behavior. Addressing key challenges in data integration and model validation the methods described in this reprint demonstrate the vast potential of these techniques to drive groundbreaking discoveries with far-reaching implications for medicine technology and neuroscience. From improving medical diagnostics to refining cognitive models and developing innovative statistical frameworks this edition strengthens our ability to analyze predict and interpret brain activity with unprecedented precision. By showcasing cutting-edge methodologies and their real-world impact we aim to inspire further research and push the boundaries of neuroscience unlocking new horizons in our understanding of the human mind.</p><p class=ql-align-justify></p>
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