<p>This book constitutes the refereed proceedings of the 22nd International Conference on Computational Methods in Systems Biology CMSB 2024 which took place in Pisa Italy during September 16-18 2024.&nbsp;</p><p>The 11 full papers included in this book were carefully reviewed and selected from 23 submissions. They deal with computational methods and tools in systems and synthetic&nbsp;biology and their applications focusing on topics such as&nbsp;modeling&nbsp;and simulation; high-performance methods for computational systems biology;&nbsp;identification of biological systems; applications of machine learning; network modeling analysis and inference; automated parameter and model synthesis;&nbsp;model integration and biological databases; multiscale modeling and analysis&nbsp;methods; design analysis and verification methods for synthetic biology; methods for biomolecular computing and engineered molecular devices; data-based&nbsp;approaches for systems and synthetic biology; optimality and control of biological systems; modeling analysis and control of microbial communities. The&nbsp;conference welcomes new theoretical results with potential applications to systems and synthetic biology as well as novel applications and case studies of&nbsp;existing methods tools or frameworks.</p>
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