Concentrated Growth Factors: A Breakthrough in Periodontal Treatment

Concentrated growth factors (CGF) was developed by Sacco in 2006CGF is a fibrin-rich organic matrix containing growth factors leukocytes platelets bone morphogenetic protein-2 (BMP-2) and CD34+ stem cells that promote regeneration. This fibrin clot exhibits high cohesion due to the agglutination of fibrinogen factor XIII and thrombin. The activation of Factor XIIIa by thrombin induces fibrin clotting offering protection against plasmin degradation and resulting in elevated fibrin tensile strength and stability It includes immunological cells crucial for controlling inflammation and reducing infection. Additionally CGF exhibits higher adhesive and tensile strength as well as higher viscosity compared to other platelet preparations.