Correlation of PPAR & Diabetic Nephropathy

Diabetic nephropathy (DN) is an important and often life-threatening microvascular complication of diabetes mellitus (DM). It is characterized by persistent albuminuria in the range of 30–299 mg/24 h (microalbuminuria) it has been shown to be the earliest sign of renal change.Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that play pivotal roles in the regulation of a very large number of biological processes such as cell proliferation cell differentiation cell death and inflammatory responses. PPARs include three known subtypes PPAR α PPAR γ and PPARβ/δ. It plays many functional roles in different organs and tissues; adipocyte differentiation lipid and glucose homeostasis and insulin sensitivity.