The present text book of COX-2 inhibitors is very informative for M. Pharm Ph. D and academic/industrial researched who are exhaustively engage with drug discovery on selective COX-2 inhibitor. This book includes enzyme structure pharmacological action Current marketed drugs Withdrawal of COX-2 drug newer COX-2 inhibitors and Drug interaction of COX-2 innibitors. We have tried graphical representation of various contents in this book for description of in simplified language and for better clarity of content.