<p><span style=color: rgba(23 43 77 1)>We have organized this Special Issue to discuss the appropriate possibilities for skin reconstruction and regeneration. Luze et al. explained how antiseptic-loaded BNC represents a promising and effective approach for the treatment of biofilms. Korzeniowski et al. demonstrated how a bromelain-based enzymatic method offers a good safe debridement option to improve the life quality of children with severe burns. Martinovic et al. wrote a paper titled Objective Skin Quality Assessment after Reconstructive Procedures for Facial Skin Defects. An interesting technique was introduced by Woo Yoo et al.-a modified mini-keystone flap technique for covering tiny volar pulp defects of the fingertip with few complications and favorable outcomes. Russo et al. conducted a comparative study between Connettivina Bio Plus and Fitostimoline Plus. They showed that both were secure and effective for treating acute superficial skin lesions. Hwan Kim et al. published A Prospective Randomized Trial Comparing Paste-Type Acellular Dermal Matrix to Standard Care for the Treatment of Chronic Wounds. Korzeniowski et al. enriched the Special Issue with a systematic review titled The Role of the Immune System in Pediatric Burns.&nbsp;Finally we presented the paper Collection of Key Surgical Techniques for the Reconstruction of Midface Skin Defects for the midface's significant role in defining important facial traits. Finally I would like to express my sincere respect to all authors for submitting excellent papers and to reviewers for taking the time to review them.</span></p>
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