DESIGN AND EVALUATION OF BILAYERED ANTI-HYPERTENSIVE TABLET

The objective of current research work was to develop sustained release formulation for antihypertensive drugs. In the present investigation polymers like Ethyl cellulose HPMC K15 and HPMC K100 were used as release reatdant materials for the formulation of bilayer sustained release tablets. Propranolol HCl were selected as the model drugs. Propranolol is beta blocker that is it blocks the action of epinephrine (adrenaline) and norepinephrine (noradrenaline) at both β1- and β2-adrenergic receptors which in turn results in reduced blood pressure and is used in treatment of hypertension. The objective of the present study was to investigate the possibility of sustaining the propranolol release from bi-layer tablet prepared by using different concentration of polymers.