Design of Synthetic DNA from First Principles - Designing Tomorrow's Life: Advancing Synthetic DNA Engineering

The author of this work wishes to design synthetic innovative information-bearing macromolecules using theoretical and computational chemistry. DNA is the prototypical information-bearing macromolecule in life and nature containing all the organism''s life information. Genetic information is encoded in the base (or nucleotide) sequence of the macromolecular DNA duplex as trinucleotide “words” or triplets. This information can be replicated infinitely by DNA replication. Messenger RNA synthesised gene by gene from the DNA template during transcription can also retrieve or pass on this information. Protein synthesis uses genetic information in messenger RNA to translate the base sequence of mRNA into the amino acid sequence of the synthesised protein using transfer RNA as an adapter.. Information-bearing macromolecules other than DNA are feasible. Nanotechnology may require molecular systems for information storage duplication and retrieval at the molecular level.. About the Author: Siamkhanthang Neihsial has a Ph.D. in Quantum Computational Chemistry from North Eastern Hill University Shillong (2010) and completed Postdoctoral Studies (2010-2017) at the Theoretical Sciences Unit Jawaharlal Nehru Centre for Advanced Scientific Research Bangalore. He was awarded the subsequent grants: I2CAM International Junior Scientist Travel Award 2012 (by National Science Foundation United States DMR-0844115 2500 USD). DST-SERB FAST Track Young Scientists Fellowship (SERB Delhi 2014-2017). Empowerment and Equity Opportunities for Excellence in Science (SERB Delhi 2023-2027) and INSA Visiting Scientist Fellowship to IIT Delhi (Indian National Science Academy Delhi 2023-2024). Currently he is an Assistant Professor and the Director of the Computational Nanoscience Laboratory in the Rayburn College Department of Chemistry.