DIAGNOSIS

Glioblastoma multiforme is the most frequent and the most aggressive primary malignant tumor of the central nervous system. Despite of the progress that has been made in therapy of many solid tumors the gold standard of glioblastoma multiforme multimodal treatment has not changed for many years. The results from clinical trials have been remained disappointing. Therefore treatment of this tumor has been challenge for neurosurgeons neuro-oncologists and radiation oncologists. In this paper risk factors prognostic/predictive factors new directions of the innovative therapeutic options in glioblastoma multiforme were discussed. Additionally complementary strategies and treatment of elderly patients were analyzed.