<p>In the United States the rate of drug shortages has significantly increased over the last 10-15&nbsp; years. The Food and Drug Administration passed the Food and Drug Administration Safety and&nbsp;Innovation Act in 2012 which requires pharmaceutical manufacturers to notify the administration of&nbsp;any changes to drug product production with the hope to prevent or mitigate any potential drug&nbsp;shortages. Various factors as to why drug shortages occur have been studied including&nbsp;manufacturing difficulties shortages of raw materials voluntary recalls natural disasters&nbsp;supply and demand issues</p><p>business and economic issues and regulatory issues.</p><p><br></p>
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