DISORDERS OF THE REGULATORY ROLE OF NITROGEN OXIDE (NO)

Cerebral pathology occupies a significant place among the causes of morbidity mortality long-term disability of modern man a decrease in his intellectual potential up to dementia personality degradation and death usually premature.Despite the great achievements of recent years in the study of the pathogenesis of the development of methods for treating acute cerebrovascular accidents (ACVA) strokes remain a serious human pathology. The urgency of the problem of stroke is associated not only with the severity of the course high mortality and disability of patients but also with the increase in the incidence and rejuvenation of strokes. A new direction in the development of pharmaceuticals apparently should be considered the creation of a special class of effective drugs that directly regulate the synthesis of endothelial NO and thereby directly improve endothelial function. Endothelial dysfunction as the earliest phase of vascular damage is associated primarily with a deficiency of NO synthesis on which structural changes in the vascular wall depend - such studies are also rare.