Drug Discovery with Privileged Building Blocks

<p>Drug Discovery with Privileged Building Blocks traces back PharmaBlock’s founding philosophy of designing privileged building blocks. High-quality building blocks are crucial not only to biological activities of different molecules but also to ADMET properties which eventually will impact the success rate of drug discovery projects. A thorough study of how building blocks perform in drug molecules and a regular analysis of new building block structures in the latest researches have proven to be a fruitful strategy to generate novel building blocks. Using this strategy PharmaBlock has supplied the drug industry with a great number of building blocks which are increasingly being adopted by drug hunters and these are identified in this book.</p><p>Each chapter may be read and studied without learning the previous chapters. This book will be a good starting point for novice medicinal chemists and veteran medicinal chemists will find it useful as well.</p><p>Key Feature</p><ol> <p> </p> <li>The book covers privileged building blocks appearing most frequently on patents for novel drugs.</li> <p> </p> <li>The latest relevant tactics are explained in the context of drug design and medicinal chemistry.</li> <p> </p> <li>Key synthesis especially large-scale synthesis is described.</li> <p> </p> <li>The most recent literature references are cited.</li> </ol>